It has been estimated that 90% of all health data in the world has been generated over the last two to three years, with diverse and ever multiplying sources such as EHRs, insurance claims but also cell phones, wearables, and more. But most of this data is still unstructured and we are still at the very beginning of exploring its potential in health to improve outcomes and accelerate research. How do we structure and turn this ever-growing big data into smart and actionable information for prevention, care and research? And how do we make sure that this flow of data is not only actionable, but also fair and ethical in all its uses? This session highlights European initiatives leading the way in making the most of data while protecting and respecting patients and data sources.